I have tested your scenario with our latest fix/version: Aspose.Cells for .NET v7.5.1.x, it works absolutely fine in IE10 browser too.
I created a sample web application /project and write the following code snippet in Page_Load event:
protected void Page_Load(object sender, EventArgs e)
Workbook workbook = new Workbook();
Worksheet worksheet = workbook.Worksheets;
workbook.Save(this.Response, “testin1.xlsx”, ContentDisposition.Attachment, new OoxmlSaveOptions(SaveFormat.Xlsx));
I can open or save the generated XLSX file without any problem in IE10 browser type. Make sure you have not put any restrictions to open download dialog box etc. in IE 10, so your files could be opened or saved properly.