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Thanks for your posting and considering Aspose.Cells.
Aspose.Cells does support the creation and manipulation of XLSX files which can support more than 65000 rows and up to 16384 columns. There is no limitation of rows and columns except what is limited by Microsoft Excel itself.
If you want to know the System Requirements of Aspose.Cells, then please see the following article for your reference.
( http://www.aspose.com/docs/display/cellsnet/System+Requirements )