When saving to the response as follows, if the file name contains a comma in Google chrome an error is shown "multiple distinct content-length headers received. this is disallowed to protect against http response-splitting attacks." with this code:
Document doc = new Document();
Aspose.Words.Saving.SaveOptions saveOptions = new Aspose.Words.Saving.DocSaveOptions();
saveOptions.SaveFormat = Aspose.Words.SaveFormat.Doc;
doc.Save(this.Response, "A,B.C.doc", ContentDisposition.Attachment, saveOptions);
The workaround is to use a memory stream and handle the output manually, however since this option is built-in you ought to fix it.