Yes, Aspose APIs are compatible with .NET 4.6. You can use the DLLs from net 2.0 folders of the installation directory of any Aspose API. Please feel free to contact us in case you have further comments or questions.
Aspose.Pdf for .NET is compatible with .NET Framework 4.5.2 and 4.6.0 and as shared by Ijaz, other API’s are also compatible with these versions. Please continue using our API’s and in case you encounter any issue, please feel free to contact.