Yes. It's possible.
You can try the following code:
Excel excel = new Excel();
for(int i = 0; i < excel.Worksheets.Count; i++)
Worksheet sheet = excel.Worksheets;
for(int j = 0; j < sheet.Cells.Count; j ++)
Cell cell = sheet.Cells[j];
However, there are some limitations:
1. Addin functions, VBA functions are not supported. So if some cells contain these functions, their value will not be updated.
2. Not all Excel built-in functions are supported. You can check the support list at http://www.aspose.com/Products/Aspose.Excel/Api/Aspose.Excel.Excel.CalculateFormula1.html .
If some functions are not supported, their values may not be updated.