I think you can use Data Binding feature provided by Aspose.Cells.GridWeb control, see some articles for your reference:
Implementing grid desktop data binding feature is worksheets
Also, see the demos:
Well, I think you may use WebCells.Export() method to export your worksheet data to fill a datatable, later you may use .NET APIs to use your own code to save it to your datasource table.
See the WebCells.Export() method API Description.