After searching through the forums, this is the only thing close to the problem we are experiencing.
Version 126.96.36.199 of .NET aspose.cells
Web Server 2008 SP2 32bit
On initial load the application can take up to 5 minutes when we replicate the following scenario.
Server connected to limited network (router with dhcp enabled but no internet access).
If we enable internet on this network or disconnect the server from the network completely, the application will load in approx 5 seconds. If we remove the aspose dll's from our bin folder the application will also load in this short time.
Using netmon we can see without the aspose dlls enabled the w3wp process will only contact akamaiitechnologies but once we copy the aspose dlls back into the bin folder netmon will show a lot of communication with ocsp.verisign.net(caused by aspose dlls?) so we can only assume that with limited network this connection is attempted but not successful which is causing the delays.
Not sure if i should have created this in the aspose.cells forum or join this old unresolved issue.