Thanks for your inquiry. Unfortunately, Aspose.Words does not provide this functionality. You can not load an opened Word document into Aspose.Words DOM and modify it.
Please note that Aspose.Words for .NET is a class library that enables your applications to perform a great range of document processing tasks. Aspose.Words supports DOC, DOCX, RTF, HTML, OpenDocument, PDF, XPS, EPUB and other formats. With Aspose.Words you can generate, modify, convert, render and print documents without utilizing Microsoft Word®. Please read more detail form here: